Current scientific work in our laboratory
Specific research areas include:
mRNA stability, epigenetics, inflammation, stem cells, ER stress, protein translation
Brain health & Heart connection
Influence of mental health on cardiovascular WELLBEING & disease
Immune cell's Eating Disorder & its effects on wound healing
Some cells die and these dead cells have to be removed from the body to maintain good health. When tissue gets injured, the dead cells are removed from injury site and normal healing ensues. The process of removal of dead cells by phagocytes (like macrophages) is called efferocytosis. Aberrant clearance leads to progression of a number of human chronic inflammatory diseases such as autoimmune and neurological disorders, diabetes, inflammatory lung diseases and atherosclerosis. We believe that if efferocytosis is perturbed during heart injury/disease, healing process is impaired leading to adverse structural remodeling and dysfunction.
Our laboratory recently discovered that mesenchymal stem cells-derived exosomes positively influences macrophage-mediated efferocytosis in the injured heart by different mechanisms. Our study published in peer-reviewed journal, Circulation Research, reports two novel molecular mechanisms. Link to the full article: doi: 10.1161/CIRCRESAHA.120.317900.
Source: Circulation Research. 2021;129:1006–1020.